Medical Technologist Test Blood Banking 3

Question 1

RhoGAM (anti-D immunoglobulin) is administered to Rh-negative mothers to prevent sensitization by doing which of the following?

Accepted Answer

Blocking fetal Rh D antigens from sensitizing the mother

Answer

RhoGAM binds to fetal Rh D-positive RBCs that entered maternal circulation, preventing them from triggering maternal anti-D alloimmunization.

Question 2

Which blood group system is most clinically significant after ABO and Rh for causing hemolytic transfusion reactions?

Accepted Answer

Kell (K)

Answer

Kell system antibodies, particularly anti-K, are strongly immunogenic and clinically significant, causing both hemolytic transfusion reactions and HDFN.

Question 3

Washed red blood cells are used for patients with which condition to prevent transfusion reactions?

Accepted Answer

Severe IgA deficiency with anti-IgA antibodies

Answer

IgA-deficient patients with anti-IgA can have anaphylactic reactions to plasma proteins; washing removes IgA from donor blood.

Question 4

A patient's forward type shows A antigen but reverse typing shows no anti-B antibody. This discrepancy is MOST likely due to which cause?

Accepted Answer

Hypogammaglobulinemia causing absent isohemagglutinins

Answer

Elderly or immunosuppressed patients with hypogammaglobulinemia may lack expected ABO isohemagglutinins, causing forward-reverse ABO discrepancies.

Question 5

Which type of transfusion reaction is caused by preformed recipient antibodies against donor HLA or granulocyte antigens?

Accepted Answer

Febrile non-hemolytic transfusion reaction (FNHTR)

Answer

FNHTR is caused by recipient antibodies reacting with donor leukocyte HLA antigens, releasing cytokines that cause fever and chills during transfusion.

Medical Technologist Test Practice Test

Medical Technologist Test Practice Test

Medical Technologist Test Blood Banking 3