Medical Technologist Test Blood Banking 2

Question 1

Hemolytic disease of the fetus and newborn (HDFN) is MOST commonly caused by antibody to which antigen?

Accepted Answer

Rh D antigen

Answer

Anti-D is the most common cause of severe HDFN; Rh-negative mothers sensitized by Rh-positive fetal RBCs produce IgG anti-D that crosses the placenta.

Question 2

What is the purpose of the antibody screen (indirect antiglobulin test) before transfusion?

Accepted Answer

Detect unexpected alloantibodies in patient serum

Answer

The antibody screen tests patient serum against commercially prepared RBCs to detect clinically significant alloantibodies before transfusion.

Question 3

Irradiation of blood products is performed primarily to prevent which transfusion complication?

Accepted Answer

Transfusion-associated graft-versus-host disease (TA-GvHD)

Answer

Gamma or X-ray irradiation inactivates donor T lymphocytes, preventing them from engrafting and attacking immunocompromised recipients (TA-GvHD).

Question 4

Platelets are stored at which temperature with continuous agitation?

Accepted Answer

20–24°C

Answer

Platelets must be stored at 20–24°C with continuous gentle agitation to prevent clumping and maintain viability; shelf life is 5–7 days.

Question 5

A positive crossmatch occurs when donor red cells are incompatible with which patient component?

Accepted Answer

Patient serum or plasma

Answer

The major crossmatch tests donor RBCs against recipient serum/plasma to detect antibodies that could destroy transfused cells.

Medical Technologist Test Practice Test

Medical Technologist Test Practice Test

Medical Technologist Test Blood Banking 2