MChem Master of Chemistry Master of Chemistry: Pharmaceutical Chemistry 5

Question 1

Which formulation strategy is used to achieve zero-order release kinetics in an oral controlled-release dosage form?

Accepted Answer

Osmotic pump (OROS) technology

Answer

Osmotic pump systems (OROS) deliver drug at a rate controlled by osmotic pressure, approximating zero-order (constant rate) release independent of GI conditions.

Question 2

In target identification using affinity-based proteomics, what role does the immobilized drug analog play?

Accepted Answer

It captures protein targets from cell lysates for subsequent identification by mass spectrometry

Answer

Immobilized drug analogs function as bait to pull down protein binding partners from complex cell lysates, which are then identified by LC-MS/MS proteomics.

Question 3

Which type of Phase I clinical trial design uses a Bayesian continual reassessment method (CRM)?

Accepted Answer

Dose-escalation study to find maximum tolerated dose

Answer

CRM is a model-based adaptive design used in Phase I dose-escalation oncology trials to estimate the MTD more efficiently than traditional 3+3 designs.

Question 4

Which endogenous enzyme system is the primary target of proton pump inhibitors (PPIs) like omeprazole?

Accepted Answer

H⁺/K⁺-ATPase in gastric parietal cells

Answer

PPIs irreversibly inhibit the H⁺/K⁺-ATPase (proton pump) in gastric parietal cells, blocking the final step of gastric acid secretion.

Question 5

Which analytical technique is used to quantify drug-plasma protein binding by separating bound from unbound drug?

Accepted Answer

Equilibrium dialysis

Answer

Equilibrium dialysis separates protein-bound drug from free drug across a semipermeable membrane, allowing accurate determination of fraction unbound (fu).

MChem Master of Chemistry Practice Test

MChem Master of Chemistry Practice Test

MChem Master of Chemistry Master of Chemistry: Pharmaceutical Chemistry 5