FREE Master of Chemistry: Pharmaceutical Chemistry Questions and Answers

Question 1

In the aforementioned reaction, dichlorocarbene, a reactive intermediate, transforms phenol into 2-hydroxy benzaldehyde.

Accepted Answer

Riemer Tiemann reaction

Answer

Shapiro reaction

Answer

Mannich reaction

Answer

Perkin reaction

Question 2

Which of the following chemical reactions produces 2,3-epoxyalcohols from primary and secondary allylic alcohols in an enantioselective manner?

Accepted Answer

Sharpless epoxidation

Answer

Smiles rearrangement

Answer

Mitsunobu reaction

Answer

Perkin reaction

Question 3

In this described reaction, which is thought to take place in two phases and involves an aldehyde, a dicarbonyl, and ammonia, the dicarbonyl and ammonia first condense to produce a diimine with an unusual orientation of N-H groups:

Accepted Answer

Debus-Radziszewski imidazole synthesis

Answer

Combe’s quinoline synthesis

Answer

Pinner pyrimidine synthesis

Answer

Knorr’s pyrazole synthesis

Question 4

Which of the following medications has two isomers, R and S, that compete with one another to engage the enzyme binding site, inhibiting the metabolism of the other isomer?

Accepted Answer

Warfarin

Answer

Felodipine

Answer

Propaphenon

Answer

Propranalol

Question 5

Which of the following antiviral medications inhibits DNA polymerase and is an adenosine analog?

Accepted Answer

Vidarabine

Answer

Ritonavir

Answer

Lamivudine

Answer

Zidovudine

Question 6

The 4-amino-5-nitrosopyrimidine and phenylacetonitrile process was originally used to create which of the following drugs?

Accepted Answer

Trimethoprim

Answer

Alprazolam

Answer

Sulfamerazine

Answer

Triamterene

Question 7

In the presence of sodium amide, 3-chloro-N-phenylbenzeneamine reacts with sulfur before being alkylated with 3-o-dimethylaminopropyl chloride.

Accepted Answer

Alprazolam

Answer

Ketoconazole

Answer

Sulfamerazine

Answer

Chloropromazine

Question 8

Which of the following is a xanthene oxidase enzyme inhibitor that works to stop the production of uric acid and treat gout?

Accepted Answer

Allopurinol

Answer

Dimercaprol

Answer

Albuterol

Answer

Pyrimethamine

Question 9

By converting its phenolic groups to Bis-dimethylcarbamate, which would otherwise undergo rapid pre-systemic metabolism, bambuterol is the prodrug of this medication used to treat asthma.

Accepted Answer

Terbutaline

Answer

Levalbuterol

Answer

Salbutamol

Answer

Albuterol

Question 10

Which of the following types of enzyme inhibitors is irreversible?

Accepted Answer

Suicide inhibitor

Answer

Competitive inhibitor

Answer

Non competitive inhibitor

Answer

uncompetitive inhibitor