MChem Master of Chemistry Master of Chemistry: Pharmaceutical Chemistry 2

Question 1

Which pharmacokinetic parameter describes the fraction of an administered dose that reaches systemic circulation unchanged?

Accepted Answer

Bioavailability

Answer

Bioavailability (F) quantifies the fraction of dose reaching systemic circulation in unchanged form, accounting for absorption and first-pass metabolism.

Question 2

In prodrug design, which bond type is most commonly used to mask a carboxylic acid to improve membrane permeability?

Accepted Answer

Ester bond

Answer

Ester bonds are used to mask carboxylic acids in prodrugs because esterases cleave them readily in vivo to regenerate the active acid.

Question 3

Which analytical technique is the gold standard for absolute stereochemical assignment in pharmaceutical compounds?

Accepted Answer

X-ray crystallography

Answer

X-ray crystallography provides definitive absolute configuration by directly mapping atomic positions in space, including stereogenic centers.

Question 4

The Lipinski Rule of Five predicts which property of drug candidates?

Accepted Answer

Oral bioavailability

Answer

Lipinski's Rule of Five uses MW ≤500, H-bond donors ≤5, H-bond acceptors ≤10, and cLogP ≤5 to predict likely oral bioavailability.

Question 5

CYP3A4 is responsible for metabolizing approximately what percentage of marketed drugs?

Accepted Answer

50–60%

Answer

CYP3A4 is the most abundant hepatic cytochrome P450 and metabolizes approximately 50–60% of marketed pharmaceuticals.

MChem Master of Chemistry Practice Test

MChem Master of Chemistry Practice Test

MChem Master of Chemistry Master of Chemistry: Pharmaceutical Chemistry 2