MCAP Pharmacology and Medication-Assisted Treatment

Question 1

Which medication for opioid use disorder acts as a full mu-opioid agonist and must be dispensed through federally certified opioid treatment programs (OTPs)?

Accepted Answer

Methadone

Answer

Buprenorphine

Answer

Naltrexone

Answer

Naloxone

Question 2

Buprenorphine exhibits a 'ceiling effect' on respiratory depression primarily because it is a:

Accepted Answer

Partial agonist at mu-opioid receptors

Answer

Full agonist at mu-opioid receptors

Answer

Full antagonist at all opioid receptors

Answer

Selective kappa-opioid receptor blocker

Question 3

Sublingual buprenorphine/naloxone (Suboxone) contains naloxone primarily to:

Accepted Answer

Prevent diversion and deter injection misuse

Answer

Enhance the analgesic potency of buprenorphine

Answer

Increase buprenorphine's oral bioavailability

Answer

Treat concurrent alcohol use disorder

Question 4

A patient receiving naltrexone for opioid use disorder requires emergency surgery. The surgical team should be informed that:

Accepted Answer

Higher-than-usual opioid doses may be needed for adequate pain control

Answer

Naltrexone enhances opioid analgesic efficacy during surgery

Answer

Naltrexone becomes fully ineffective within 6 hours of the last dose

Answer

Regional anesthesia is absolutely contraindicated with naltrexone

Question 5

Which of the following represents a contraindication to initiating buprenorphine treatment for opioid use disorder?

Accepted Answer

Full opioid agonist use within the past 12-24 hours without signs of withdrawal

Answer

Active daily tobacco smoking

Answer

History of benzodiazepine use disorder currently in remission

Answer

Co-occurring depression managed with an SSRI

Question 6

Extended-release injectable naltrexone (Vivitrol) offers which primary clinical advantage over oral naltrexone for OUD patients?

Accepted Answer

Removes the daily adherence requirement, significantly improving medication compliance

Answer

Provides mild opioid agonist effects to prevent withdrawal symptoms

Answer

Eliminates the need for liver function monitoring

Answer

Can be initiated without requiring a period of opioid abstinence

Question 7

According to evidence-based research, medications for opioid use disorder (MOUD) compared to behavioral therapy alone demonstrate:

Accepted Answer

Superior outcomes in reducing illicit opioid use and overdose mortality

Answer

Similar outcomes when patient motivation is sufficiently high

Answer

Better results only for patients with severe, long-term OUD

Answer

Equivalent effectiveness but higher patient satisfaction ratings