Blood Banking and Transfusion Medicine Flashcards
7 cards from real Laboratory Science practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Blood Banking and Transfusion Medicine flashcards as text
Which Rh antigen is the most clinically significant and is the basis for Rh-positive/Rh-negative typing?
Answer: D antigen
The D antigen is the most immunogenic Rh antigen and determines whether a person is classified as Rh-positive or Rh-negative.
What is the maximum allowable storage time for fresh frozen plasma (FFP) stored at -18°C or below?
Answer: 1 year (12 months)
FFP stored at -18°C or below has a shelf life of 1 year; once thawed, it must be transfused within 24 hours.
The weak D test is performed primarily to:
Answer: Detect weak expression of the D antigen in apparently Rh-negative individuals
Weak D testing identifies individuals with reduced or qualitatively different D antigen expression, preventing misclassification as Rh-negative.
Leukoreduction of blood products is performed primarily to:
Answer: Reduce febrile non-hemolytic transfusion reactions and CMV transmission risk
Removing donor white blood cells reduces febrile non-hemolytic transfusion reactions caused by donor leukocyte antigens and cytokines, and decreases the risk of CMV transmission.
What is the primary purpose of irradiating blood products before transfusion?
Answer: Prevent transfusion-associated graft-versus-host disease (TA-GvHD)
Irradiation inactivates donor T-lymphocytes, preventing them from engrafting and attacking tissues in immunocompromised recipients (TA-GvHD).
Which blood group system is the most clinically significant after the ABO system?
Answer: Rh system
The Rh system is the second most clinically significant blood group due to its high immunogenicity and role in hemolytic transfusion reactions and hemolytic disease of the fetus and newborn.
What is the maximum volume collected in a standard whole blood donation?
Answer: 450-500 mL
Standard whole blood donations collect 450-500 mL (approximately one pint or 10% of total blood volume) to ensure donor safety.