KAPS Pharmacology Fundamentals 2

Question 1

Which pharmacokinetic parameter describes the fraction of an administered dose that reaches systemic circulation unchanged?

Accepted Answer

Bioavailability

Answer

Bioavailability (F) is the fraction of administered drug that reaches systemic circulation in unchanged form.

Question 2

A drug with a narrow therapeutic index requires more careful dosing because:

Accepted Answer

The toxic dose is close to the therapeutic dose

Answer

A narrow therapeutic index means there is little difference between the minimum effective concentration and the minimum toxic concentration.

Question 3

Which type of drug-receptor interaction is characterized by a drug that binds to a receptor and produces a submaximal effect even at full receptor occupancy?

Accepted Answer

Partial agonist

Answer

A partial agonist activates receptors but produces a lower maximal effect (Emax) than a full agonist, even at 100% receptor occupancy.

Question 4

First-pass metabolism most significantly affects drugs administered by which route?

Accepted Answer

Oral

Answer

Orally administered drugs pass through the portal circulation to the liver before reaching systemic circulation, where extensive first-pass metabolism can significantly reduce bioavailability.

Question 5

The ED50 of a drug refers to the dose that produces the desired effect in:

Accepted Answer

50% of the test population

Answer

ED50 is the effective dose that produces the desired therapeutic response in 50% of the population studied.

(KAPS) Knowledge Assessment of Pharmaceutical Sciences Practice Test

(KAPS) Knowledge Assessment of Pharmaceutical Sciences Practice Test

KAPS Pharmacology Fundamentals 2