KAPS Pharmacokinetics and Biopharmaceutics

Question 1

Which pharmacokinetic parameter represents the time required for the plasma drug concentration to decrease by 50%?

Accepted Answer

Elimination half-life

Answer

Volume of distribution

Answer

Bioavailability

Answer

Protein binding fraction

Question 2

What is the bioavailability of a drug administered intravenously?

Accepted Answer

100%

Answer

50%

Answer

75%

Answer

90%

Question 3

Which pharmacokinetic process describes the reversible transfer of a drug from the bloodstream into body tissues and organs?

Accepted Answer

Distribution

Answer

Absorption

Answer

Metabolism

Answer

Excretion

Question 4

Volume of distribution (Vd) is BEST described as:

Accepted Answer

A hypothetical volume relating total drug in the body to plasma concentration

Answer

The actual plasma volume in the body (approximately 3 L)

Answer

The total body water volume (approximately 42 L)

Answer

The volume of urine produced per day

Question 5

Which factors PRIMARILY determine the rate of drug absorption from the gastrointestinal tract?

Accepted Answer

Drug lipophilicity and dissolution rate

Answer

Drug molecular weight alone

Answer

Plasma protein binding capacity

Answer

Hepatic blood flow

Question 6

First-pass metabolism is BEST defined as:

Accepted Answer

Drug metabolism in the liver before the drug reaches systemic circulation

Answer

The initial phase of renal drug elimination

Answer

The first metabolic step occurring in plasma proteins

Answer

Drug breakdown by stomach acid

Question 7

For a drug with a HIGH hepatic extraction ratio administered orally, which factor MOST significantly affects its systemic exposure?

Accepted Answer

Changes in hepatic blood flow

Answer

Changes in renal blood flow

Answer

Changes in plasma protein binding

Answer

Changes in gastric pH