KAPS Pharmaceutical Chemistry and Analysis 2

Question 1

Which spectroscopic technique measures the absorption of infrared radiation to identify functional groups in a drug molecule?

Accepted Answer

Infrared spectroscopy

Answer

Infrared spectroscopy identifies functional groups based on characteristic bond vibration frequencies in the IR region.

Question 2

The Henderson-Hasselbalch equation is used to calculate which property of a drug?

Accepted Answer

Degree of ionization at a given pH

Answer

The Henderson-Hasselbalch equation relates pH, pKa, and the ratio of ionized to unionized drug forms.

Question 3

Which type of isomerism occurs when two compounds have the same molecular formula but differ in the connectivity of atoms?

Accepted Answer

Constitutional isomerism

Answer

Constitutional (structural) isomers share the same molecular formula but have different atom connectivity.

Question 4

In HPLC, what does the term 'resolution' describe?

Accepted Answer

The degree of separation between two adjacent peaks

Answer

Resolution quantifies how well two adjacent chromatographic peaks are separated from each other.

Question 5

Which bond type is primarily responsible for the double-helix stability of DNA and is also important in drug-receptor interactions?

Accepted Answer

Hydrogen bonds

Answer

Hydrogen bonds stabilize the DNA double helix between base pairs and are critical in many drug-receptor binding events.

(KAPS) Knowledge Assessment of Pharmaceutical Sciences Practice Test