KAPS Clinical Procedures and Protocols 2

Question 1

A pharmacist is reviewing a medication order for vancomycin. Which pharmacokinetic parameter is most important to monitor for efficacy in serious infections?

Accepted Answer

AUC/MIC ratio

Answer

Vancomycin efficacy is best predicted by the AUC/MIC ratio, with a target AUC24/MIC ≥400 recommended by current guidelines.

Question 2

When preparing a sterile IV admixture in a horizontal laminar airflow workbench (LAFW), the pharmacist should work at least how far inside the hood?

Accepted Answer

6 inches

Answer

USP <797> requires that all critical manipulations be performed at least 6 inches inside the LAFW to ensure sterile airflow protection.

Question 3

A patient on warfarin is started on fluconazole. What INR monitoring adjustment is most appropriate?

Accepted Answer

Check INR more frequently and adjust warfarin based on results

Answer

Fluconazole inhibits CYP2C9 and significantly increases warfarin levels, so more frequent INR monitoring with dose adjustment is required.

Question 4

Which of the following is the correct procedure for reconstituting a lyophilized powder for injection?

Accepted Answer

Direct the diluent stream against the vial wall

Answer

Directing diluent against the vial wall prevents foaming and protein denaturation, ensuring proper reconstitution.

Question 5

A 70 kg patient with a creatinine clearance of 15 mL/min requires gentamicin. Which dosing strategy is most appropriate?

Accepted Answer

Reduced dose at extended interval

Answer

Severe renal impairment requires both dose reduction and interval extension for aminoglycosides to prevent accumulation and nephrotoxicity.

(KAPS) Knowledge Assessment of Pharmaceutical Sciences Practice Test

(KAPS) Knowledge Assessment of Pharmaceutical Sciences Practice Test

KAPS Clinical Procedures and Protocols 2