HSR Vulnerable Populations Protection 2

Question 1

Which characteristic most commonly designates a population as 'vulnerable' in human subjects research?

Accepted Answer

Susceptibility to undue influence or coercion

Answer

Vulnerability in research ethics centers on the reduced ability to protect oneself from exploitation, coercion, or undue influence.

Question 2

Under 45 CFR 46 Subpart B, fetal research is permissible when:

Accepted Answer

It poses no added risk to the fetus and holds prospect of direct benefit

Answer

Subpart B allows fetal research only when risk to the fetus is minimized and the research offers the prospect of direct benefit or is scientifically important with minimal risk.

Question 3

In research involving cognitively impaired adults, which safeguard is most essential?

Accepted Answer

Obtaining surrogate consent from a legally authorized representative

Answer

When an adult lacks decision-making capacity, a legally authorized representative must provide surrogate consent to protect the individual's interests.

Question 4

When recruiting employees as research participants, the most significant ethical concern is:

Accepted Answer

Hierarchical coercion stemming from employer-employee relationships

Answer

Employees may feel implicitly pressured to participate by supervisors or fear negative employment consequences for declining, constituting undue influence.

Question 5

An IRB reviewing a study that compensates low-income participants with a large cash payment should be concerned about:

Accepted Answer

Whether the payment constitutes undue inducement to participate

Answer

Excessive compensation can undermine voluntariness by inducing economically disadvantaged individuals to accept risks they would otherwise decline.

HSR - Human Subjects Research Certification Practice Test

HSR - Human Subjects Research Certification Practice Test

HSR Vulnerable Populations Protection 2