GI GI Pharmacology & Medications

Question 1

Which class of drugs is used as first-line therapy for gastroesophageal reflux disease (GERD) by irreversibly inhibiting the H+/K+ ATPase pump?

Accepted Answer

Proton pump inhibitors

Answer

Proton pump inhibitors (PPIs) like omeprazole irreversibly block the gastric proton pump, providing the most effective acid suppression for GERD.

Question 2

What is the mechanism of action of metoclopramide in GI disorders?

Accepted Answer

Blocks dopamine receptors to enhance gastric motility

Answer

Metoclopramide is a dopamine antagonist that accelerates gastric emptying and reduces nausea by enhancing upper GI motility.

Question 3

Which antibiotic combination is used in H. pylori triple therapy alongside a proton pump inhibitor?

Accepted Answer

Amoxicillin + clarithromycin

Answer

Standard H. pylori triple therapy consists of a PPI plus amoxicillin and clarithromycin for 10–14 days.

Question 4

Which medication is used to treat C. difficile colitis as the preferred first-line agent over metronidazole?

Accepted Answer

Vancomycin (oral)

Answer

Oral vancomycin is now the preferred first-line treatment for C. difficile infection due to superior clinical cure rates.

Question 5

Mesalamine (5-ASA) is primarily used to treat which GI condition?

Accepted Answer

Inflammatory bowel disease (ulcerative colitis and Crohn's)

Answer

Mesalamine is an anti-inflammatory aminosalicylate used to induce and maintain remission in inflammatory bowel disease, especially ulcerative colitis.

(GI) Gastrointestinal Practice Test

(GI) Gastrointestinal Practice Test

GI GI Pharmacology & Medications