FREE Master of Pharmacy: Pharmaceutical Formulations and Dosage Forms Questions and Answers
Choose the term from the list that best describes how it works inside a compressed tablet after it has been exposed to moisture. Mechanism of Action of Disintegrants: Sodium starch glyconate
The correct answer is: "Overall swelling - a significant increase in volume". Sodium starch glyconate, as a disintegrant, undergoes significant swelling upon exposure to moisture, resulting in an overall increase in volume. This swelling causes the tablet to break apart, enhancing its dissolution rate. Therefore, the answer accurately describes the mechanism of action of sodium starch glyconate as a disintegrant.
This is about how the next tablet for a new medicine should be made. Wet granulation is used to make the tablets, and the drug is known to be hard to dissolve:
xy1000(active) ....................................350mg
Lactose, USP Powder .......................106mg
Microcrystalline cellulose ...............90 mg
PVP ...........................................................30mg
Sodium starch glycolate NF ............18mg
Magnesium stearate ...........................6mg
Total Tablet Weight 600mg
If you replace sodium starch glycolate with the same amount of starch, the rate at which XY1000 dissolves from the tablets is likely to________?
The correct answer is "decrease". Replacing sodium starch glycolate with an equal amount of starch in the formulation is likely to result in a decreased dissolution rate of XY1000 from the tablets. Sodium starch glycolate is a disintegrant that aids in tablet breakup and dissolution, and substituting it with starch may lead to reduced disintegration efficiency and slower drug release. Therefore, the selected answer accurately suggests that the dissolution rate is expected to decrease with this substitution.
When making low-dose tablets of highly potent drugs by direct compression, the biggest problem is getting the drug content to be uniform and homogeneous enough.
The correct answer is: TRUE. The statement accurately reflects that while direct compression avoids exposing a drug to heat and moisture, it doesn't significantly reduce the number of steps involved in tablet manufacturing compared to other methods like wet granulation. Therefore, the assertion that direct compression doesn't substantially decrease the steps required for tablet production is correct.
Which of the following liquids can't be used to carry soft gelatin capsule fill materials?
The correct answer is "Polysorbate 80". Among the options provided, "Polysorbate 80" is not suitable for carrying soft gelatin capsule fill materials. While cottonseed oil and polyethylene glycol 400 are commonly used as carriers in soft gelatin capsules, polysorbate 80 may not provide the required compatibility or stability for certain fill materials. Therefore, the selected answer accurately identifies Polysorbate 80 as the liquid that cannot be used to carry soft gelatin capsule fill materials.
This is about how the next tablet for a new medicine should be made. Wet granulation is used to make the tablets, and the drug is known to be hard to dissolve:
xy1000(active) ....................................350mg
Lactose, USP Powder .......................106mg
Microcrystalline cellulose ...............90 mg
PVP ...........................................................30mg
Sodium starch glycolate NF ............18mg
Magnesium stearate ...........................6mg
Total Tablet Weight 600mg
If magnesium stearate was replaced in the formula with an equal amount of calcium stearate, the dissolution rate of xy1000 from the tablets would be expected to _____?
The correct answer is "have a little effect on". Substituting magnesium stearate with an equal amount of calcium stearate might cause a minor impact on the dissolution rate of xy1000 from the tablets. While both stearates are lubricants, the small change in formulation is unlikely to significantly alter the dissolution properties. Therefore, the selected answer accurately reflects that the substitution would have a modest influence on the dissolution rate.
In general, the amount of force used to make a tablet is directly related to how hard it is and how easily it breaks.
The correct answer is: FALSE. The statement is not accurate. While it's true that the compressive force applied during tablet manufacturing affects tablet characteristics, the amount of force is not directly related to how hard the tablet is or how easily it breaks. Factors like formulation, excipients, and compression speed also influence tablet hardness and friability. Therefore, the statement's assertion is false.
Even though direct compression keeps a drug from being exposed to heat and moisture, it doesn't really cut down on the number of steps needed to make a tablet.
The correct answer is: False. Direct compression is a tablet manufacturing method that eliminates the wet granulation process, thereby reducing the number of steps required for tablet production compared to other methods. Although it avoids exposing the drug to heat and moisture, it does contribute to a streamlined manufacturing process. Therefore, the statement's assertion that it doesn't reduce the number of steps is inaccurate.
Choose the term from the list that best describes how it works inside a compressed tablet after it has been exposed to moisture. Mechanism of Action of Disintegrants: Croscarmellose
Croscarmellose is a disintegrant that, upon exposure to moisture, undergoes radial swelling of its deformed fiber-shaped particles, causing them to straighten out. This expansion facilitates the breakup of the tablet into smaller particles, aiding in rapid dissolution. Therefore, the answer accurately describes the mechanism of action of Croscarmellose as a disintegrant.
The best way to add the sodium starch glycolate is:
The correct answer is "50% intragranularly / 50% extragranularly". The most effective method to incorporate sodium starch glycolate is by adding it both intragranularly and extragranularly in equal proportions (50% each). This approach optimizes its disintegration properties during tablet dissolution, promoting efficient breakup and drug release. Therefore, the selected answer accurately reflects the recommended method for adding sodium starch glycolate.
Microcrystalline cellulose can't be used to make a tablet of a large dose of a drug that doesn't pack down well.
The correct answer is: FALSE. The statement is not accurate. Microcrystalline cellulose is commonly used as a filler and binder in tablet formulations, even for drugs with poor compaction properties or low dose. It aids in improving compressibility, flowability, and binding characteristics, making it possible to create tablets of large doses and poorly compactable drugs through direct compression. Therefore, the assertion that microcrystalline cellulose can't be used for poorly compactable drugs or large doses is incorrect.
A common filler and binder in chewable tablets is:
The correct answer is " None of the above". Among the options provided, "Dipac" and "Ditab" are not typically recognized as common filler-binders in chewable tablets. Calcium carbonate, however, is a widely used filler and binder in chewable tablets due to its properties that enhance tablet characteristics. Therefore, the chosen answer is incorrect, as none of the provided options accurately represent a common filler-binder used in chewable tablets.
This is about how the next tablet for a new medicine should be made. Wet granulation is used to make the tablets, and the drug is known to be hard to dissolve:
xy1000(active) ....................................350mg
Lactose, USP Powder .......................106mg
Microcrystalline cellulose ...............90 mg
PVP ...........................................................30mg
Sodium starch glycolate NF ............18mg
Magnesium stearate ...........................6mg
Total Tablet Weight 600mg
Increasing the force of compression to 1000 kg is likely to slow down the rate at which the material breaks down.
The correct answer is "cannot predict without more information". While increasing the compression force can potentially impact the disintegration rate, the effect depends on various factors such as the specific formulation and characteristics of the material. Without additional details about the tablet composition and behavior, it's uncertain whether the rate at which the material breaks down would slow down or be affected differently. Therefore, the chosen answer correctly indicates that the outcome cannot be determined without more information.
This is about how the next tablet for a new medicine should be made. Wet granulation is used to make the tablets, and the drug is known to be hard to dissolve:
xy1000(active) ....................................350mg
Lactose, USP Powder .......................106mg
Microcrystalline cellulose ...............90 mg
PVP ...........................................................30mg
Sodium starch glycolate NF ............18mg
Magnesium stearate ...........................6mg
Total Tablet Weight 600mg
If you cut the time it takes to mix the lubricant from 15 minutes to 2 minutes, the rate at which xy1000 dissolves from the tablets is likely to _______?
The correct answer is" increase". Reducing the lubricant blending time from 15 minutes to 2 minutes could lead to an increased dissolution rate of xy1000 from the tablets. A shorter blending time might result in less uniform distribution of the lubricant, potentially allowing for faster tablet disintegration and drug release. Therefore, the selected answer accurately indicates that the dissolution rate is likely to increase with this change.
Choose the term from the list that best describes how it works inside a compressed tablet after it has been exposed to moisture. Mechanism of Action of Disintegrants: Starch
The correct answer is "Recovers shape with little or no increase in volume". Starch, as a disintegrant, maintains its original shape within a tablet while undergoing minimal volume increase upon exposure to moisture. Unlike other disintegrants that significantly swell or deform, starch helps the tablet fragments disintegrate by its ability to recover its shape without significant expansion. Therefore, the answer accurately describes the mechanism of action of starch as a disintegrant.
True lubricants reduce the force needed to eject a tablet by lowering the force left in the die wall.
The correct answer is: FALSE. The statement is not accurate. True lubricants in tablet manufacturing do help in easing the tablet ejection process by reducing friction between the tablet and the die walls, but they don't specifically lower the force left in the die wall. Instead, they minimize adhesion between the tablet and die, aiding in smoother ejection. Therefore, the assertion that true lubricants reduce ejection force by lowering the force left in the die wall is incorrect.
As soon as the punch goes into the die, the first step in making a tablet is elastic deformation.
The correct answer is: False. In tablet compaction, the initial step when the punch enters the die is plastic deformation, not elastic deformation. Elastic deformation refers to reversible changes in shape, whereas plastic deformation involves permanent changes in shape due to compression forces. Therefore, the statement is not accurate.