FPGEE MCQ Exam Flashcards
7 cards from real FPGEE practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 FPGEE MCQ Exam flashcards as text
A pharmacist is counseling a patient on how to administer insulin glargine. Which statement is correct?
Answer: It must be administered once daily at any consistent time and never mixed
Insulin glargine is a peakless basal insulin given once daily and cannot be mixed with other insulins because altering its pH destroys its slow-release properties.
Which vitamin deficiency is MOST likely in a strict vegan who has not taken any supplements for 5 years?
Answer: Vitamin B12 (cobalamin)
Vitamin B12 is found almost exclusively in animal products; strict vegans are at high risk of B12 deficiency leading to megaloblastic anemia and neuropathy.
A drug follows first-order kinetics with a half-life of 6 hours. Approximately how long until steady-state is reached with regular dosing?
Answer: 30 hours
Steady-state is achieved after approximately 4–5 half-lives; 5 × 6 hours = 30 hours.
Which antifungal mechanism involves binding to ergosterol and forming pores in the fungal cell membrane?
Answer: Polyenes (amphotericin B)
Amphotericin B and other polyenes bind directly to ergosterol in the fungal membrane, forming pores that cause leakage of intracellular contents.
Under the Drug Quality and Security Act (DQSA), which category of compounders is regulated directly by the FDA as an outsourcing facility?
Answer: 503B outsourcing facilities producing large-scale sterile preparations
503B outsourcing facilities voluntarily register with the FDA, allowing large-scale compounding of sterile preparations without patient-specific prescriptions under federal oversight.
A patient receiving vancomycin for MRSA bacteremia has a trough level of 8 mg/L. What is the appropriate clinical action?
Answer: Increase dose or frequency to achieve AUC/MIC ≥ 400
Current ASHP/IDSA guidelines recommend AUC-guided vancomycin dosing targeting AUC/MIC ≥ 400; a trough of 8 mg/L suggests subtherapeutic exposure for serious infections.
Which electrolyte abnormality is MOST commonly associated with loop diuretic therapy?
Answer: Hypokalemia and hypomagnesemia
Loop diuretics inhibit the Na-K-2Cl cotransporter in the thick ascending limb, causing substantial urinary losses of potassium and magnesium.