A critically ill patient requires prolonged broad-spectrum antibiotics. Which intervention BEST reduces the risk of Clostridioides difficile-associated diarrhea?
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A
Routine oral vancomycin prophylaxis
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B
De-escalating antibiotics to the narrowest effective spectrum as soon as possible
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C
Starting prophylactic metronidazole concurrently
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D
Adding a probiotic to the enteral feed