FFICM Research and Development 4

Question 1

The CONSORT statement is a reporting guideline primarily used for which type of study?

Accepted Answer

Randomised controlled trials

Answer

CONSORT (Consolidated Standards of Reporting Trials) provides a checklist and flow diagram to improve the transparency and completeness of RCT reporting.

Question 2

In a study evaluating a new biomarker for early AKI detection in ICU patients, the AUC-ROC is 0.85. How should this be interpreted?

Accepted Answer

There is an 85% probability that the biomarker ranks a randomly selected AKI patient higher than a non-AKI patient

Answer

The AUC-ROC represents the probability that the model ranks a randomly chosen positive case higher than a randomly chosen negative case, quantifying overall discriminative ability.

Question 3

A Phase II ICU trial tests three doses of a novel sedative. The primary purpose of this trial phase is to:

Accepted Answer

Assess safety and determine appropriate dosing

Answer

Phase II trials evaluate preliminary efficacy, safety, and dose-finding in a moderate-sized population before proceeding to a definitive Phase III trial.

Question 4

Which method is used to adjust for multiple confounders simultaneously in an observational ICU study to estimate the effect of an intervention?

Accepted Answer

Multivariable logistic or Cox regression

Answer

Multivariable regression allows simultaneous adjustment for several confounders to obtain a more unbiased estimate of the exposure-outcome association.

Question 5

A propensity score analysis is conducted in an ICU study. The propensity score represents:

Accepted Answer

The probability of receiving the treatment given observed baseline characteristics

Answer

The propensity score is the conditional probability of treatment assignment given observed covariates, used to balance groups in observational studies.

(FFICM) Final Faculty of Intensive Care Medicine Practice Test

(FFICM) Final Faculty of Intensive Care Medicine Practice Test

FFICM Research and Development 4