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Coagulation and Transfusion Medicine Flashcards

7 cards from real EDAIC practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. A trauma patient receives 10 units of packed red blood cells. Which electrolyte abnormality is most expected from massive transfusion?

    Answer: Hyperkalemia

    Stored red blood cells release potassium over time, leading to hyperkalemia with massive transfusion.

  2. Which test best reflects the extrinsic coagulation pathway?

    Answer: Prothrombin time (PT)

    Prothrombin time (PT) measures the extrinsic pathway (tissue factor/Factor VII) and common pathway.

  3. A patient on warfarin requires emergency reversal. Which agent provides the most rapid and complete reversal?

    Answer: 4-factor prothrombin complex concentrate (4F-PCC)

    4-factor PCC provides immediate reversal of vitamin K antagonists with a smaller volume and faster effect than FFP.

  4. In heparin-induced thrombocytopenia (HIT), which anticoagulant is preferred for ongoing anticoagulation?

    Answer: Argatroban

    Argatroban is a direct thrombin inhibitor not derived from heparin and is safe to use in HIT.

  5. Which component of the massive transfusion protocol is primarily given to replace fibrinogen?

    Answer: Cryoprecipitate

    Cryoprecipitate is rich in fibrinogen, Factor VIII, von Willebrand factor, and Factor XIII.

  6. A patient with renal failure develops prolonged bleeding time with normal PT and aPTT. What is the most likely mechanism?

    Answer: Platelet dysfunction due to uremic toxins

    Uremia impairs platelet adhesion and aggregation by interfering with GPIb-von Willebrand factor interaction.

  7. Which viscoelastic test parameter represents clot formation rate?

    Answer: Alpha angle (TEG/ROTEM)

    The alpha angle reflects the rate of clot formation and fibrin cross-linking in both TEG and ROTEM.

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