Practice Test Geeks(DPM) Doctor of Podiatric Medicine Practice Test
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Pharmacology & Therapeutics Flashcards

7 cards from real DPM practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

Read the first 7 Pharmacology & Therapeutics flashcards as text

  1. Which class of medication used for diabetic peripheral neuropathy acts by inhibiting the reuptake of both serotonin and norepinephrine?

    Answer: SNRIs

    SNRIs such as duloxetine are FDA-approved for diabetic peripheral neuropathy and work by inhibiting serotonin-norepinephrine reuptake.

  2. A podiatrist performs a digital nerve block using lidocaine with epinephrine. What is the primary risk associated with epinephrine in this location?

    Answer: Digital ischemia and necrosis

    Epinephrine causes vasoconstriction in digital end-arteries, risking ischemia and necrosis in toes, making it contraindicated for digital blocks.

  3. Colchicine is used to treat acute gout. At the cellular level, what is its primary mechanism?

    Answer: Binds tubulin and inhibits microtubule polymerization

    Colchicine binds tubulin dimers and prevents microtubule assembly, impairing neutrophil migration and phagocytosis of urate crystals.

  4. A patient with MRSA foot osteomyelitis requires IV antibiotic therapy. Which agent has excellent bone penetration and is active against MRSA?

    Answer: Vancomycin

    Vancomycin remains a first-line agent for MRSA osteomyelitis with adequate bone penetration and proven efficacy.

  5. Which prostaglandin analogue is used topically to treat onychomycosis via a different mechanism than azoles or allylamines?

    Answer: Ciclopirox

    Ciclopirox is a hydroxypyridinone antifungal that chelates polyvalent cations essential for fungal enzymes, unlike azoles or allylamines.

  6. A patient taking metformin for type 2 diabetes requires an IV contrast study for a vascular foot lesion. What is the primary concern regarding metformin?

    Answer: Lactic acidosis risk from contrast-induced nephropathy

    Contrast-induced nephropathy can reduce metformin clearance, leading to accumulation and potentially fatal lactic acidosis.

  7. Which bisphosphonate is used in Charcot neuroarthropathy to inhibit osteoclast activity and potentially slow bone destruction?

    Answer: Zoledronic acid

    Zoledronic acid (zoledronate) is the most potent bisphosphonate and has been studied for reducing bone turnover in acute Charcot neuroarthropathy.

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