Practice Test Geeks(DPM) Doctor of Podiatric Medicine Practice Test
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Pharmacology & Therapeutics Flashcards

7 cards from real DPM practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

Read the first 7 Pharmacology & Therapeutics flashcards as text

  1. A patient with gout is started on allopurinol. Which mechanism best describes how this drug reduces uric acid levels?

    Answer: Inhibits xanthine oxidase

    Allopurinol is a xanthine oxidase inhibitor that reduces conversion of hypoxanthine and xanthine to uric acid.

  2. Which topical antifungal is classified as an allylamine and is first-line for tinea pedis (athlete's foot)?

    Answer: Terbinafine

    Terbinafine, an allylamine, inhibits squalene epoxidase and is highly effective for dermatophyte infections like tinea pedis.

  3. A diabetic patient requires local anesthesia for a minor foot procedure. Which local anesthetic has the LONGEST duration of action?

    Answer: Bupivacaine

    Bupivacaine has a duration of action of 4–8 hours, making it the longest-acting amide local anesthetic commonly used in podiatric procedures.

  4. Probenecid is used as adjunctive therapy in gout management. What is its primary mechanism?

    Answer: Blocks renal tubular reabsorption of uric acid (uricosuric)

    Probenecid is a uricosuric agent that inhibits URAT1 transporter in the proximal tubule, blocking reabsorption and increasing urinary uric acid excretion.

  5. A patient on warfarin for DVT develops a foot infection requiring antibiotics. Which antibiotic class is MOST likely to significantly increase warfarin's INR?

    Answer: Fluoroquinolones

    Fluoroquinolones inhibit CYP1A2 and reduce vitamin K-producing gut flora, significantly potentiating warfarin's anticoagulant effect.

  6. Which opioid analgesic is considered SAFEST in patients with severe renal impairment due to lack of active metabolite accumulation?

    Answer: Fentanyl

    Fentanyl is hepatically metabolized to inactive metabolites and does not accumulate dangerously in renal impairment, unlike morphine or codeine.

  7. A patient develops contact dermatitis from a topical antibiotic used post-operatively on a foot wound. Which agent is MOST commonly implicated?

    Answer: Bacitracin

    Bacitracin is one of the most common causes of allergic contact dermatitis among topical antibiotics due to its high sensitization rate.

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