DO Pharmacology and Therapeutics 2

Question 1

A patient prescribed an SSRI for depression develops agitation, hyperthermia, and clonus after adding tramadol. What syndrome is occurring?

Accepted Answer

Serotonin syndrome

Answer

Neuroleptic malignant syndrome

Answer

Malignant hyperthermia

Answer

Anticholinergic toxicity

Question 2

Which beta-blocker is cardioselective (β1-selective) and preferred in patients with mild asthma requiring heart rate control?

Accepted Answer

Metoprolol

Answer

Propranolol

Answer

Carvedilol

Answer

Labetalol

Question 3

The antidote for acetaminophen overdose, N-acetylcysteine (NAC), works by which mechanism?

Accepted Answer

Replenishing glutathione stores to detoxify NAPQI

Answer

Directly binding acetaminophen in the gut

Answer

Inhibiting CYP2E1 to reduce toxic metabolite formation

Answer

Alkalinizing urine to enhance excretion

Question 4

Which drug used for gout acts by inhibiting xanthine oxidase to reduce uric acid production?

Accepted Answer

Allopurinol

Answer

Colchicine

Answer

Probenecid

Answer

Indomethacin

Question 5

A patient on lithium develops nausea, tremor, and confusion. Which medication should be reviewed as a potential cause of lithium toxicity?

Accepted Answer

Ibuprofen (NSAID)

Answer

Acetaminophen

Answer

Diphenhydramine

Answer

Amoxicillin

Question 6

Which anticoagulant requires no routine INR monitoring and acts by directly inhibiting thrombin (Factor IIa)?

Accepted Answer

Dabigatran

Answer

Warfarin

Answer

Rivaroxaban

Answer

Apixaban