Dermatologist Certificate General 3

Question 1

A patient with HIV develops painful, grouped vesicles along a unilateral thoracic dermatome. What is the treatment of choice?

Accepted Answer

Oral valacyclovir

Answer

Herpes zoster in immunocompromised patients is treated with oral valacyclovir or famciclovir; IV acyclovir is reserved for severe or disseminated disease.

Question 2

Which gene is most commonly mutated in patients with familial melanoma?

Accepted Answer

CDKN2A

Answer

CDKN2A (encoding p16/INK4A) is the most commonly mutated gene in familial melanoma, significantly increasing lifetime risk.

Question 3

Nikolsky's sign is positive in which of the following conditions?

Accepted Answer

Pemphigus vulgaris

Answer

Nikolsky's sign — lateral pressure causing epidermal slippage — is positive in pemphigus vulgaris due to loss of keratinocyte cohesion from anti-desmoglein antibodies.

Question 4

Which topical medication is first-line for rosacea papulopustular subtype?

Accepted Answer

Topical metronidazole

Answer

Topical metronidazole is a first-line treatment for papulopustular rosacea due to its anti-inflammatory and antimicrobial properties.

Question 5

The Koebner phenomenon refers to the appearance of skin lesions at sites of:

Accepted Answer

Trauma or injury

Answer

The Koebner (isomorphic) phenomenon occurs when skin disease appears at sites of trauma, classically seen in psoriasis, vitiligo, and lichen planus.

Dermatologist Certificate Practice Test

Dermatologist Certificate Practice Test

Dermatologist Certificate General 3