Dermatologist Certificate Dermatopharmacology and Topical Therapy 2

Question 1

Which systemic medication requires monthly pregnancy tests and two forms of contraception due to severe teratogenicity?

Accepted Answer

Isotretinoin

Answer

Isotretinoin is highly teratogenic, causing severe fetal malformations, and requires enrollment in the iPLEDGE program with mandatory monthly pregnancy testing and dual contraception.

Question 2

Dupilumab (Dupixent) works by blocking the receptor for which cytokines in atopic dermatitis?

Accepted Answer

IL-4 and IL-13

Answer

Dupilumab is a monoclonal antibody that blocks the IL-4Rα subunit shared by IL-4 and IL-13 receptors, inhibiting the Th2 inflammatory cascade central to atopic dermatitis.

Question 3

What is the most serious adverse effect associated with long-term use of high-potency topical corticosteroids?

Accepted Answer

Skin atrophy with telangiectasias and striae

Answer

Prolonged use of high-potency topical steroids causes skin atrophy, striae distensae, telangiectasias, and purpura due to reduced collagen synthesis and thinning of all skin layers.

Question 4

IL-17A inhibitors (secukinumab, ixekizumab) are approved for which dermatological condition?

Accepted Answer

Moderate-to-severe plaque psoriasis

Answer

Secukinumab and ixekizumab target IL-17A, a key downstream cytokine in the IL-23/Th17 axis, and are FDA-approved for moderate-to-severe plaque psoriasis with excellent efficacy.

Question 5

Dapsone is used in dermatology primarily for which two conditions?

Accepted Answer

Dermatitis herpetiformis and leprosy

Answer

Dapsone is the drug of choice for dermatitis herpetiformis and is a key component of multidrug therapy for leprosy, working through anti-inflammatory and antimicrobial mechanisms.

Dermatologist Certificate Practice Test

Dermatologist Certificate Practice Test

Dermatologist Certificate Dermatopharmacology and Topical Therapy 2