CTR Cancer Biology & Pathology 1

Question 1

In ICD-O-3, what does a behavior code of '/3' indicate?

Accepted Answer

Malignant, primary site

Answer

Behavior code '/3' in ICD-O-3 designates a malignant primary site tumor, distinguishing it from benign ('/0'), borderline ('/1'), and metastatic ('/6') designations.

Question 2

Which histologic type of lung cancer is most commonly diagnosed in non-smokers and women?

Accepted Answer

Adenocarcinoma

Answer

Adenocarcinoma is the most frequent lung cancer subtype in non-smokers and women, often arising peripherally in the lung and associated with EGFR mutations.

Question 3

Carcinoma in situ (CIS) is best defined as:

Accepted Answer

Malignant cells confined to the epithelium with no basement membrane invasion

Answer

Carcinoma in situ consists of malignant epithelial cells that have not yet breached the basement membrane, making it non-invasive by definition.

Question 4

Tumor grade primarily describes which characteristic of a neoplasm?

Accepted Answer

The degree of cellular differentiation relative to normal tissue

Answer

Tumor grade reflects how closely cancer cells resemble normal cells microscopically; low-grade tumors are well-differentiated and high-grade tumors are poorly differentiated.

Question 5

Adenocarcinoma is a malignancy arising from which tissue type?

Accepted Answer

Glandular epithelium

Answer

Adenocarcinoma (prefix 'adeno-') originates from glandular epithelial cells and is common in organs such as the colon, breast, lung, and prostate.

(CTR) Certified Tumor Registrar Practice Test

(CTR) Certified Tumor Registrar Practice Test

CTR Cancer Biology & Pathology 1