CTP Organ Preservation Techniques 5

Question 1

What is the role of prostaglandin E1 (PGE1) in lung preservation during procurement?

Accepted Answer

Pulmonary vasodilation to ensure uniform distribution of flush solution

Answer

PGE1 is administered before lung flush to dilate the pulmonary vasculature, ensuring uniform distribution of cold preservation solution throughout the lungs.

Question 2

In normothermic regional perfusion (NRP) for DCD donors, what is the primary goal of excluding the cerebral circulation?

Accepted Answer

To prevent restoration of brain perfusion in a legally dead donor

Answer

Cerebral vessels are ligated or clamped during NRP to ensure no blood flow is restored to the brain, preserving the legal and ethical basis of death determination.

Question 3

Which preservation solution is most commonly used for small bowel transplantation due to its ability to limit mucosal injury?

Accepted Answer

University of Wisconsin (UW) solution

Answer

UW solution is the standard for small bowel preservation, providing optimal protection for the ischemia-sensitive intestinal mucosa.

Question 4

Which parameter measured during hypothermic machine perfusion (HMP) of a kidney indicates vascular damage that predicts poor graft outcome?

Accepted Answer

Persistently elevated resistive index (RI > 0.4)

Answer

A persistently high RI during HMP indicates irreversible vascular damage and is associated with increased risk of delayed graft function or non-function.

Question 5

What is the primary metabolic substrate provided to organs during normothermic machine perfusion (NMP) to support aerobic metabolism?

Accepted Answer

Red blood cells as oxygen carriers combined with glucose

Answer

NMP perfusate contains packed red blood cells to carry oxygen and glucose as the primary energy substrate to sustain aerobic cellular metabolism.

(CTP) Certified Transplant Preservationist Practice Test

(CTP) Certified Transplant Preservationist Practice Test

CTP Organ Preservation Techniques 5