CTP CTP Transplant Pharmacology & Preservation Solutions

Question 1

Which preservation solution is considered the gold standard for cold static storage of abdominal organs such as the kidney and liver?

Accepted Answer

University of Wisconsin (UW) solution

Answer

Euro-Collins solution

Answer

Custodiol HTK solution

Answer

Celsior solution

Question 2

What is the primary role of impermeants such as lactobionate in organ preservation solutions?

Accepted Answer

Prevent cellular swelling by limiting osmotic fluid influx

Answer

Provide energy substrate for cellular metabolism

Answer

Neutralize free radicals during reperfusion

Answer

Maintain electrolyte balance in the preservation fluid

Question 3

Histidine-Tryptophan-Ketoglutarate (HTK) solution, also known as Custodiol, is most commonly used for preservation of which organ in the US?

Accepted Answer

Heart

Answer

Kidney

Answer

Pancreas

Answer

Intestine

Question 4

Which additive in preservation solutions acts as an oxygen free radical scavenger to reduce ischemia-reperfusion injury?

Accepted Answer

Allopurinol

Answer

Potassium chloride

Answer

Sodium bicarbonate

Answer

Mannitol

Question 5

What is the recommended target temperature range (°C) for cold static storage of most solid organs during preservation?

Accepted Answer

0–4°C

Answer

5–8°C

Answer

10–12°C

Answer

15–18°C

Question 6

Which preservation solution component is primarily responsible for maintaining colloid osmotic pressure and preventing interstitial edema in the graft?

Accepted Answer

Hydroxyethyl starch (HES)

Answer

Potassium phosphate

Answer

Magnesium sulfate

Answer

Adenosine