CTP Organ Preservation Techniques 4

Question 1

What is the primary purpose of flushing organs with cold preservation solution immediately after cross-clamp?

Accepted Answer

Rapidly cool the organ and wash out blood to halt metabolism

Answer

Rapid cooling with preservation flush halts metabolic activity and removes blood that would otherwise clot or cause hypoxic injury.

Question 2

In ex vivo lung perfusion (EVLP), a PO₂/FiO₂ ratio greater than which value generally indicates acceptable lung function for transplant?

Accepted Answer

400 mmHg

Answer

A PaO₂/FiO₂ ratio >400 mmHg on EVLP is considered a threshold for acceptable oxygenation function prior to transplantation.

Question 3

Which of the following best describes 'primary graft dysfunction' (PGD) in lung transplantation and its relationship to preservation?

Accepted Answer

Ischemia-reperfusion injury causing acute lung injury within 72 hours post-transplant

Answer

PGD is a form of ischemia-reperfusion injury that manifests as acute lung injury within 72 hours and is directly linked to preservation quality.

Question 4

Which preservation technique is most appropriate for a marginal kidney from an older DCD donor to maximize viability assessment?

Accepted Answer

Hypothermic machine perfusion (HMP) with viability monitoring

Answer

HMP allows continuous viability monitoring (flow, resistance, lactate) for marginal DCD kidneys while also reducing ischemic injury.

Question 5

What is the significance of 'back-table preparation' during organ transplantation?

Accepted Answer

Trimming and preparing the organ's vasculature for anastomosis while maintaining cold storage

Answer

Back-table preparation involves trimming excess tissue, ligating accessory vessels, and preparing vascular cuffs while keeping the organ cold to minimize warm ischemia.

(CTP) Certified Transplant Preservationist Practice Test

(CTP) Certified Transplant Preservationist Practice Test

CTP Organ Preservation Techniques 4