CTP CTP Transplant Pharmacology & Preservation Solutions

Question 1

Which preservation solution is considered the gold standard for cold static storage of abdominal organs such as the kidney and liver?

Accepted Answer

University of Wisconsin (UW) solution

Answer

University of Wisconsin (UW) solution has been the gold standard for cold static storage of abdominal organs due to its ability to maintain cellular integrity during prolonged ischemia.

Question 2

What is the primary role of impermeants such as lactobionate in organ preservation solutions?

Accepted Answer

Prevent cellular swelling by limiting osmotic fluid influx

Answer

Impermeants like lactobionate prevent cellular swelling by creating an osmotic barrier that limits the influx of water and sodium into cells during cold storage.

Question 3

Histidine-Tryptophan-Ketoglutarate (HTK) solution, also known as Custodiol, is most commonly used for preservation of which organ in the US?

Accepted Answer

Heart

Answer

HTK/Custodiol is widely used for cardiac preservation in the US due to its low viscosity allowing rapid cooling and its buffering capacity provided by histidine.

Question 4

Which additive in preservation solutions acts as an oxygen free radical scavenger to reduce ischemia-reperfusion injury?

Accepted Answer

Allopurinol

Answer

Allopurinol inhibits xanthine oxidase, reducing the generation of oxygen free radicals that cause cellular damage during ischemia-reperfusion injury.

Question 5

What is the recommended target temperature range (°C) for cold static storage of most solid organs during preservation?

Accepted Answer

0–4°C

Answer

Cold static storage is performed at 0–4°C to slow cellular metabolism and minimize ischemic injury without causing ice crystal formation.

(CTP) Certified Transplant Preservationist Practice Test

(CTP) Certified Transplant Preservationist Practice Test

CTP CTP Transplant Pharmacology & Preservation Solutions