CTP CTP Transplant Pharmacology & Preservation Solutions 2

Question 1

Immunosuppressant medications given during organ preservation flush are intended primarily to:

Accepted Answer

Prevent early acute rejection at reperfusion

Answer

Immunosuppressants administered during the preservation flush help blunt the early immune response upon reperfusion, reducing the risk of hyperacute or acute rejection.

Question 2

Which vasoactive agent is commonly added to preservation flushes to achieve maximal vasodilation of the donor organ vasculature?

Accepted Answer

Prostaglandin E1 (PGE1)

Answer

Prostaglandin E1 is a potent vasodilator added to preservation flushes to ensure uniform distribution of the solution throughout the organ's microvasculature.

Question 3

In the context of organ preservation, what does the term 'cold ischemia time' (CIT) specifically refer to?

Accepted Answer

Time from cold flush to reperfusion in the recipient

Answer

Cold ischemia time begins when the organ is flushed with cold preservation solution and ends when blood flow is restored to the organ in the recipient.

Question 4

Which electrolyte concentration in preservation solutions most closely mimics intracellular fluid to protect cells during hypothermic storage?

Accepted Answer

High potassium, low sodium

Answer

Intracellular-type preservation solutions with high potassium and low sodium mimic the intracellular environment, preventing the electrolyte shifts that cause cellular dysfunction during cold storage.

Question 5

What is the maximum acceptable cold ischemia time (in hours) for a standard-criteria kidney transplant to achieve optimal outcomes?

Accepted Answer

24 hours

Answer

Kidney transplants are ideally performed within 24 hours of cold ischemia time, as prolonged cold storage significantly increases the risk of delayed graft function.

(CTP) Certified Transplant Preservationist Practice Test

(CTP) Certified Transplant Preservationist Practice Test

CTP CTP Transplant Pharmacology & Preservation Solutions 2