Donor & Recipient Evaluation Flashcards
7 cards from real CTP practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Donor & Recipient Evaluation flashcards as text
A donor is found to have a hepatocellular carcinoma (HCC) incidentally discovered at procurement. Which organ may still be considered for transplantation in most protocols?
Answer: Kidneys
Kidneys are generally considered low risk for HCC transmission because primary liver malignancies rarely metastasize to the kidneys prior to procurement.
Which hemodynamic parameter is used to guide fluid resuscitation during donor management to optimize organ perfusion?
Answer: Central venous pressure (CVP) of 4–10 mmHg
Maintaining CVP between 4–10 mmHg in brain-dead donors helps optimize cardiac preload without causing pulmonary edema.
Donor-derived transmission of which organism is a well-documented risk requiring recipient prophylaxis in the early post-transplant period?
Answer: Toxoplasma gondii
Toxoplasma gondii can be transmitted from a seropositive donor heart to a seronegative recipient, necessitating post-transplant prophylaxis with TMP-SMX.
In the context of expanded criteria donor (ECD) kidneys, which recipient group benefits most from use of these organs?
Answer: Older recipients with shorter expected remaining dialysis-free survival
Older recipients on dialysis gain survival benefit from ECD kidneys because even marginal kidney function often exceeds the mortality risk of remaining on dialysis.
Which viral infection in a potential organ donor requires special disclosure to the transplant team and may restrict organ use to consenting recipients?
Answer: Active West Nile virus (WNV) infection
Active WNV infection in a donor can be transmitted through organs and carries significant neurological morbidity; use is restricted to life-threatening situations with recipient consent.
What is the primary purpose of performing a crossmatch between donor lymphocytes and recipient serum before transplantation?
Answer: To detect pre-formed donor-specific antibodies that could cause hyperacute rejection
The crossmatch identifies pre-formed donor-specific antibodies (DSAs) in recipient serum that would bind donor antigens and cause hyperacute or accelerated rejection.
A donor's urine output drops to 20 mL/hr despite adequate hydration and dopamine. Which additional intervention is most appropriate?
Answer: Initiate vasopressin infusion
Vasopressin (ADH) replacement is indicated in brain-dead donors with diabetes insipidus, which commonly causes oliguria and hemodynamic instability.