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CTP Organ Viability Assessment & Machine Perfusion Flashcards

6 cards from real CTP practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. What is the primary advantage of hypothermic machine perfusion (HMP) over cold static storage for kidney preservation?

    Answer: Continuous washout of metabolic waste products and delivery of nutrients

    Hypothermic machine perfusion continuously removes metabolic waste products and delivers nutrients and oxygen to the organ, reducing ischemic injury compared to static cold storage.

  2. Which perfusion parameter measured during hypothermic machine perfusion (HMP) is most predictive of early graft function after kidney transplantation?

    Answer: Resistance index (vascular resistance)

    Vascular resistance measured during HMP is the most predictive parameter of post-transplant graft function, with lower resistance generally indicating better organ viability.

  3. In normothermic machine perfusion (NMP) of the liver, what substrate is essential to include in the perfusate to maintain hepatocyte function?

    Answer: Red blood cells (RBCs) to provide oxygen delivery

    Red blood cells must be included in normothermic liver perfusate to carry adequate oxygen to hepatocytes, which have high metabolic demands at physiologic temperature.

  4. During normothermic regional perfusion (NRP) of abdominal organs in a DCD donor, what is the primary physiologic goal?

    Answer: Restore aerobic metabolism and allow cellular repair before procurement

    Normothermic regional perfusion restores oxygenated blood flow to abdominal organs after cardiac arrest, allowing cells to resume aerobic metabolism and repair ischemic damage before procurement.

  5. What is the Kidney Donor Profile Index (KDPI), and what value is considered the threshold for 'expanded criteria donor' status?

    Answer: A risk score from 0–100%; KDPI ≥85% defines high-risk/ECD kidneys

    The KDPI is a 0–100% risk score predicting graft longevity; kidneys with KDPI ≥85% are considered high-risk and were historically classified as expanded criteria donor (ECD) kidneys.

  6. Lactate clearance in the perfusate during normothermic machine perfusion (NMP) of a liver is used as a viability marker because:

    Answer: A functioning liver actively metabolizes lactate, indicating restored aerobic metabolism

    A viable liver under normothermic perfusion will metabolize and clear lactate, demonstrating restored aerobic metabolic function and hepatocellular integrity.