Medication and Component Handling Flashcards

When compounding a sterile preparation using a powdered drug that requires reconstitution, which diluent should be used unless otherwise specified?

Answer: Sterile water for injection (SWFI)

Sterile water for injection (SWFI) is the default diluent for reconstitution unless the manufacturer specifies an alternative, as it is preservative-free and sterile.

Which practice best prevents cross-contamination when handling multiple hazardous drug preparations in a BSC?

Answer: Cleaning the BSC with 70% IPA between each preparation

Cleaning the BSC with 70% isopropyl alcohol between preparations prevents carryover contamination from one hazardous drug to another.

A technician must compound a preparation requiring an ingredient with a known photosensitivity. Which handling method is appropriate?

Answer: Wrap the final container in amber or opaque material and minimize light exposure

Photosensitive drugs must be protected from light during compounding and storage by using amber containers or opaque wrapping.

What is the purpose of performing a 'fingertip sampling' test during cleanroom training for sterile compounding personnel?

Answer: To verify proper gowning and aseptic hand technique by culturing fingertip samples

Fingertip sampling cultures the fingertips post-gowning to verify that aseptic technique and gloving procedures adequately reduce bioburden.

When labeling a compounded sterile preparation for a patient, which element is NOT required on the label per USP ?

Answer: The compounder's DEA registration number

A DEA registration number is required only for controlled substances, not on all CSP labels; required elements include BUD, route, and storage conditions.

Which action should be taken if an ampule is found to have a hairline crack before use in sterile compounding?

Answer: Discard the ampule and document the rejection

A cracked ampule must be discarded and the rejection documented, as integrity cannot be guaranteed and contamination risk is unacceptable.

What is the significance of an 'inhibitory residue test' for cleaning agents used in sterile compounding areas?

Answer: It verifies that cleaning agent residues will not interfere with sterility testing results

Inhibitory residue testing ensures cleaning agent residues left on compounding surfaces will not falsely suppress microbial growth in sterility tests, ensuring accurate results.