Medication and Component Handling Flashcards

What is the significance of checking the expiration date of each ingredient before compounding?

Answer: Using expired ingredients violates USP 797 and may result in a subpotent or contaminated product

USP 797 prohibits the use of expired ingredients in CSPs.

When using a 0.22-micron sterilizing filter, what must be verified after filtration?

Answer: Filter integrity using a bubble point test or manufacturer-recommended method

After sterilizing filtration, filter integrity must be verified to confirm the membrane was intact.

What is the correct procedure for handling a drug vial stored in a refrigerator before use?

Answer: Allow it to reach room temperature before use to prevent condensation

Refrigerated vials should equilibrate to room temperature to prevent condensation that could introduce contamination.

Why must a filter needle be changed to a regular needle after withdrawing from a glass ampule?

Answer: The filter needle may release trapped glass particles if used to inject

Glass particles trapped in the filter could be expelled into the final container if the same needle is used for injection.

What should a technician do if they notice particulate matter in a commercially manufactured IV solution?

Answer: Do not use it; quarantine and report to the pharmacist for investigation

A commercially manufactured product with visible particulates should not be used and must be quarantined and reported.

What is the purpose of checking NDC numbers during the compounding verification process?

Answer: To verify the correct drug, strength, and manufacturer of each ingredient

NDC numbers uniquely identify a drug product by manufacturer, drug name, strength, dosage form, and package size.