CRNA CRNA Pharmacology and Anesthesia Agents 2

Question 1

What is the primary clinical use of dexmedetomidine in anesthesia practice?

Accepted Answer

Sedation without respiratory depression

Answer

Dexmedetomidine is a selective alpha-2 agonist that provides sedation, anxiolysis, and analgesia with minimal respiratory depression, making it ideal for monitored anesthesia care.

Question 2

Which volatile anesthetic is associated with the highest risk of nephrotoxicity due to Compound A formation?

Accepted Answer

Sevoflurane

Answer

Sevoflurane reacts with carbon dioxide absorbents (particularly dried soda lime) to produce Compound A, a potentially nephrotoxic vinyl ether, especially at low fresh gas flows.

Question 3

Ketamine's dissociative anesthetic effect is primarily mediated through which receptor?

Accepted Answer

NMDA receptor antagonism

Answer

Ketamine produces dissociative anesthesia primarily by non-competitive antagonism of NMDA receptors, blocking glutamate-mediated excitation.

Question 4

Which drug should be immediately available when administering intrathecal opioids to manage the most serious potential complication?

Accepted Answer

Naloxone

Answer

Naloxone is the opioid antagonist required to reverse delayed respiratory depression, the most serious complication of intrathecal opioid administration.

Question 5

What is the primary advantage of using sugammadex over neostigmine for reversal of rocuronium-induced neuromuscular blockade?

Accepted Answer

Reversal at any depth of blockade without antimuscarinic need

Answer

Sugammadex encapsulates rocuronium (and vecuronium) directly, enabling reversal from profound blockade without the muscarinic side effects that require anticholinergic co-administration.

CRNA - Certified Registered Nurse Anesthetist Practice Test

CRNA - Certified Registered Nurse Anesthetist Practice Test

CRNA CRNA Pharmacology and Anesthesia Agents 2