CPR Opioid Overdose Response and Naloxone

Question 1

What are the three classic signs of opioid overdose, known as the 'opioid overdose triad'?

Accepted Answer

Pinpoint pupils, unconsciousness, and respiratory depression (slow or absent breathing)

Answer

Fever, vomiting, and rapid heart rate

Answer

Dilated pupils, agitation, and tachycardia

Answer

Chest pain, diaphoresis, and arm weakness

Question 2

How does naloxone (Narcan) reverse opioid overdose?

Accepted Answer

It competitively binds to opioid receptors, displacing opioids and reversing their effects

Answer

It metabolizes opioids in the bloodstream and removes them

Answer

It stimulates the heart to beat faster

Answer

It constricts blood vessels to increase blood pressure

Question 3

What is the recommended initial adult dose of intranasal naloxone for opioid overdose reversal?

Accepted Answer

4 mg intranasally (one full actuation of the 4 mg/0.1 mL device)

Answer

0.4 mg (1 mL of 0.4 mg/mL solution)

Answer

10 mg intranasally

Answer

0.1 mg intranasally

Question 4

After administering naloxone to a suspected opioid overdose victim who is not responding, what is the appropriate next action?

Accepted Answer

If no response in 2-3 minutes, administer a second dose of naloxone and continue rescue breathing

Answer

Wait 30 minutes for the drug to work before doing anything else

Answer

Stop all resuscitation efforts

Answer

Administer a stimulant to increase heart rate

Question 5

What is 'renarcotization' in the context of naloxone administration?

Accepted Answer

The return of overdose symptoms when naloxone wears off before the opioid has been metabolized, requiring repeat doses or continued monitoring

Answer

The process of re-administering opioids after treatment

Answer

An allergic reaction to naloxone

Answer

A withdrawal syndrome caused by naloxone

Question 6

Which of the following opioid reversal routes is preferred for rapid emergency use by bystanders?

Accepted Answer

Intramuscular (IM) or intranasal (IN)

Answer

Intravenous (IV)

Answer

Subcutaneous (SQ)

Answer

Oral (PO)

Question 7

What is the 'Evzio' auto-injector in the context of opioid overdose response?

Accepted Answer

An FDA-approved naloxone auto-injector that provides voice instructions to guide lay users through administration

Answer

An electronic monitoring device for opioid overdose detection

Answer

A newer opioid medication for pain management

Answer

A naloxone tablet for oral administration

Question 8

Why might multiple doses of naloxone be required when treating a fentanyl overdose compared to a heroin overdose?

Accepted Answer

Fentanyl and its analogs are significantly more potent than heroin, binding mu-opioid receptors with much higher affinity, requiring larger or repeated naloxone doses to displace

Answer

Fentanyl is a less potent opioid requiring more medication to reverse

Answer

Fentanyl does not cause respiratory depression

Answer

Naloxone does not work for fentanyl overdose

Question 9

What should a bystander do if a suspected opioid overdose victim begins to vomit after naloxone administration?

Accepted Answer

Roll the person into the recovery position (on their side) immediately to prevent aspiration

Answer

Continue rescue breathing regardless of vomiting

Answer

Administer more naloxone

Answer

Perform abdominal thrusts

Question 10

Does administering naloxone to a non-opioid-dependent person who has overdosed on opioids cause withdrawal symptoms?

Accepted Answer

No, withdrawal symptoms from naloxone only occur in opioid-dependent individuals; non-dependent people simply wake up and recover

Answer

Yes, naloxone always causes withdrawal regardless of dependence

Answer

Yes, naloxone causes seizures in everyone who receives it

Answer

No, naloxone has no side effects of any kind