CPHON Tumor Types, Staging, and Treatment Modalities

Question 1

Which pediatric cancer is associated with a characteristic abdominal mass that does not cross the midline in young children?

Accepted Answer

Wilms' tumor (nephroblastoma)

Answer

Neuroblastoma

Answer

Hepatoblastoma

Answer

Rhabdomyosarcoma

Question 2

Neuroblastoma most commonly arises from which tissue?

Accepted Answer

Adrenal medulla and sympathetic ganglia

Answer

Bone marrow

Answer

Liver parenchyma

Answer

Renal cortex

Question 3

Which staging system is used for Wilms' tumor?

Accepted Answer

Children's Oncology Group (COG) Wilms' Tumor staging (Stage I–V)

Answer

Ann Arbor staging

Answer

FIGO staging

Answer

Dukes staging

Question 4

A child is diagnosed with Stage IV Hodgkin lymphoma. Which modality is MOST commonly used in treatment?

Accepted Answer

Combination chemotherapy with or without radiation

Answer

Surgery alone

Answer

Radiation alone

Answer

Targeted antibody therapy alone

Question 5

A child with osteosarcoma is most likely to present with which clinical finding?

Accepted Answer

Localized bone pain worsened at night with soft tissue swelling

Answer

Painless abdominal mass

Answer

Bilateral lower extremity weakness

Answer

Generalized lymphadenopathy

Question 6

Which characteristic feature on imaging is seen in Ewing sarcoma?

Accepted Answer

Onion-skin periosteal reaction

Answer

Dense osteoblastic lesion

Answer

Codman triangle and sunburst pattern

Answer

Lytic lesion with calcification