CPHON Pediatric Blood Disorders and Hematology 3

Question 1

A child with leukemia has a platelet count of 10,000/mm³ and no active bleeding. Prophylactic platelet transfusion is typically indicated at this threshold to prevent:

Accepted Answer

Spontaneous hemorrhage

Answer

Bone marrow failure

Answer

Febrile neutropenia

Answer

Tumor lysis syndrome

Question 2

A child receiving hydroxyurea for sickle cell disease should have which monitoring performed regularly?

Accepted Answer

Complete blood count and reticulocyte count

Answer

Pulmonary function tests

Answer

Bone density scans

Answer

Liver biopsy

Question 3

When irradiated blood products are ordered for a pediatric oncology patient, the PRIMARY reason is to prevent:

Accepted Answer

Transfusion-associated GVHD

Answer

Alloimmunization to platelets

Answer

CMV transmission

Answer

Iron overload

Question 4

The nurse is caring for a child post-bone marrow transplant with a CMV-negative status. Which blood product should be ordered?

Accepted Answer

CMV-seronegative or leukoreduced blood products

Answer

Non-irradiated packed red blood cells

Answer

Fresh whole blood

Answer

ABO-incompatible platelets

Question 5

A child with neutrophil count of 1,800/mm³ develops fever of 38.5°C. According to CPHON guidelines, this child:

Accepted Answer

Does not meet criteria for febrile neutropenia

Answer

Has febrile neutropenia and requires urgent evaluation

Answer

Can be observed at home for 24 hours

Answer

Should receive prophylactic antifungals only

Question 6

A child with hemophilia B is bleeding after a fall. The appropriate treatment is replacement with:

Accepted Answer

Factor IX concentrate

Answer

Factor VIII concentrate

Answer

Fresh frozen plasma alone

Answer

Vitamin K