CPHON Chemotherapy Administration and Safety 2

Question 1

Which chemotherapy class works by cross-linking DNA strands to prevent cell replication?

Accepted Answer

Alkylating agents

Answer

Antimetabolites

Answer

Topoisomerase inhibitors

Answer

Vinca alkaloids

Question 2

When administering L-asparaginase, the nurse's PRIORITY assessment is monitoring for:

Accepted Answer

Anaphylaxis

Answer

Alopecia

Answer

Mucositis

Answer

Constipation

Question 3

A pediatric patient is receiving continuous infusion of 5-fluorouracil. Which assessment finding warrants immediate notification of the provider?

Accepted Answer

Chest pain and cardiac arrhythmia

Answer

Mild nausea

Answer

Temporary hair thinning

Answer

Low-grade fever of 37.8°C

Question 4

What is the recommended maximum cumulative lifetime dose of doxorubicin in pediatric patients to minimize cardiotoxicity?

Accepted Answer

450–550 mg/m²

Answer

100 mg/m²

Answer

200 mg/m²

Answer

1,000 mg/m²

Question 5

A child is prescribed bleomycin as part of a lymphoma protocol. Which baseline test is MOST important before starting therapy?

Accepted Answer

Pulmonary function tests

Answer

Echocardiogram

Answer

Renal ultrasound

Answer

Bone marrow biopsy

Question 6

Which chemotherapy agent is classified as a topoisomerase II inhibitor and requires cardiac monitoring?

Accepted Answer

Etoposide

Answer

Vincristine

Answer

Cytarabine

Answer

Busulfan