COMLEX-USA Pharmacology 2

Question 1

Statins (HMG-CoA reductase inhibitors) lower LDL cholesterol primarily by:

Accepted Answer

Upregulating hepatic LDL receptors

Answer

Increasing bile acid excretion

Answer

Inhibiting intestinal cholesterol absorption

Answer

Activating lipoprotein lipase

Question 2

Which antiepileptic drug works by blocking sodium channels and is a first-line treatment for partial and generalized tonic-clonic seizures?

Accepted Answer

Phenytoin

Answer

Ethosuximide

Answer

Valproic acid

Answer

Benzodiazepines

Question 3

The antidote for acetaminophen overdose, N-acetylcysteine (NAC), works by:

Accepted Answer

Replenishing glutathione stores

Answer

Directly binding NAPQI

Answer

Inhibiting CYP2E1

Answer

Alkalinizing the urine

Question 4

Which receptor does naloxone antagonize to reverse opioid overdose?

Accepted Answer

Mu (μ) receptor primarily

Answer

Kappa (κ) receptor only

Answer

Delta (δ) receptor only

Answer

Sigma (σ) receptor

Question 5

Lithium toxicity is increased by which commonly prescribed drug class due to reduced renal clearance?

Accepted Answer

NSAIDs

Answer

Beta-blockers

Answer

ACE inhibitors (NSAIDs both decrease lithium excretion)

Answer

Calcium channel blockers

Question 6

Which antimalarial drug causes hemolytic anemia in patients with G6PD deficiency?

Accepted Answer

Primaquine

Answer

Chloroquine

Answer

Mefloquine

Answer

Atovaquone