COMAT Preventive Medicine and Public Health 2

Question 1

The CAGE questionnaire screens for which condition using four questions about cutting down, annoyance, guilt, and eye-openers?

Accepted Answer

Alcohol use disorder

Answer

The CAGE questionnaire is a validated 4-item screening tool for alcohol use disorder; a score of ≥2 indicates a clinically significant alcohol problem.

Question 2

A new drug reduces the absolute risk of myocardial infarction from 4% to 2% over 5 years. What is the number needed to treat (NNT)?

Accepted Answer

50

Answer

NNT = 1 / absolute risk reduction = 1 / (0.04 − 0.02) = 1 / 0.02 = 50, meaning 50 patients must be treated to prevent one additional MI.

Question 3

Which BMI range defines Class I obesity in adults according to standard clinical guidelines?

Accepted Answer

30.0–34.9 kg/m²

Answer

Class I obesity is defined as BMI 30.0–34.9 kg/m²; Class II is 35.0–39.9, and Class III (severe) is ≥40.0 kg/m².

Question 4

Which pharmacotherapy is considered the most effective first-line agent for smoking cessation due to partial agonism at nicotinic acetylcholine receptors?

Accepted Answer

Varenicline (Chantix)

Answer

Varenicline is the most efficacious first-line pharmacotherapy for smoking cessation, acting as a partial agonist at α4β2 nicotinic acetylcholine receptors to reduce cravings and withdrawal.

Question 5

Which malignancy is strongly associated with occupational asbestos exposure, typically presenting 20–40 years after exposure?

Accepted Answer

Mesothelioma

Answer

Mesothelioma is a malignant tumor of the pleura or peritoneum with a long latency period, and asbestos exposure is its predominant risk factor.

COMAT - Comprehensive Osteopathic Medical Achievement Test Practice Test

COMAT - Comprehensive Osteopathic Medical Achievement Test Practice Test

COMAT Preventive Medicine and Public Health 2