COCN COCN Hematologic Malignancies 2

Question 1

Which finding on a peripheral blood smear is characteristic of chronic myeloid leukemia (CML)?

Accepted Answer

Left shift with cells at all stages of myeloid maturation

Answer

CML shows a left shift with myeloid cells at all maturation stages, reflecting uncontrolled granulocyte production.

Question 2

A patient with Hodgkin lymphoma reports drenching night sweats, unexplained fever, and 12% weight loss. These are classified as:

Accepted Answer

B symptoms

Answer

B symptoms (fever >38°C, drenching night sweats, >10% weight loss) indicate systemic disease and affect staging in lymphoma.

Question 3

Which medication class is the standard first-line treatment for CML targeting the BCR-ABL oncoprotein?

Accepted Answer

Tyrosine kinase inhibitors (TKIs)

Answer

TKIs such as imatinib, dasatinib, and nilotinib directly inhibit BCR-ABL kinase activity in CML.

Question 4

Reed-Sternberg cells are pathognomonic for which lymphoma type?

Accepted Answer

Hodgkin lymphoma

Answer

Large binucleated Reed-Sternberg cells with prominent owl-eye nucleoli are the defining histologic feature of Hodgkin lymphoma.

Question 5

Which electrolyte imbalance is NOT a feature of tumor lysis syndrome (TLS)?

Accepted Answer

Hypercalcemia

Answer

TLS causes hypocalcemia (not hypercalcemia) due to phosphate binding calcium as phosphate is released from lysed cells.

COCN Test Practice Test