Treatment Protocols & Therapeutic Interventions Flashcards

The current extended time window for mechanical thrombectomy in selected large-vessel occlusion patients chosen by perfusion imaging is up to:

Answer: 24 hours

The DAWN and DEFUSE-3 trials support thrombectomy up to 24 hours from last known well for selected patients with a clinical-core or perfusion mismatch.

In spontaneous intracerebral hemorrhage, which systolic BP target is commonly recommended when presenting SBP is 150–220 mmHg?

Answer: About 140 mmHg

Guidelines support lowering SBP to about 140 mmHg (and avoiding below 130) to limit hematoma growth.

Which agent is preferred to reverse warfarin-associated intracranial hemorrhage?

Answer: 4-factor prothrombin complex concentrate plus IV vitamin K

4F-PCC corrects INR faster than FFP, and IV vitamin K keeps the reversal going.

Idarucizumab is the specific reversal agent for which anticoagulant?

Answer: Dabigatran

Idarucizumab is a monoclonal antibody fragment that binds dabigatran, a direct thrombin inhibitor.

First-line treatment for Guillain-Barré syndrome in a patient who cannot walk on their own is:

Answer: IVIG 2 g/kg over 5 days or plasma exchange

IVIG and plasma exchange are equally effective in GBS, and corticosteroids show no benefit.

Which bedside measurement best signals the need for intubation in a patient with Guillain-Barré syndrome?

Answer: Forced vital capacity below 20 mL/kg

The 20/30/40 rule (FVC <20 mL/kg, NIF weaker than −30, PEF <40% of predicted) signals impending respiratory failure.

In status epilepticus, the initial IM midazolam dose for an adult over 40 kg without IV access is:

Answer: 10 mg

Per the RAMPART trial, adults over 40 kg get 10 mg IM midazolam, which works as well as IV lorazepam.