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Hematology & Coagulation Flashcards

7 cards from real CMT practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

Read the first 7 Hematology & Coagulation flashcards as text

  1. The Philadelphia chromosome, t(9;22) producing BCR-ABL1, is the hallmark of which disorder?

    Answer: Chronic myeloid leukemia

    BCR-ABL1 creates a constitutively active tyrosine kinase that drives CML.

  2. Which leukemia carries the greatest risk of disseminated intravascular coagulation at diagnosis?

    Answer: Acute promyelocytic leukemia

    Abnormal promyelocytes in APL, t(15;17), release procoagulant granule contents that trigger DIC.

  3. Numerous smudge cells with many small, mature-appearing lymphocytes in an elderly patient suggest:

    Answer: Chronic lymphocytic leukemia

    Fragile CLL lymphocytes rupture during smear preparation, leaving smudge (basket) cells.

  4. Which cytochemical stain is characteristically positive in hairy cell leukemia?

    Answer: Tartrate-resistant acid phosphatase

    Hairy cells keep acid phosphatase activity after tartrate treatment, giving a positive TRAP stain.

  5. A markedly LOW leukocyte alkaline phosphatase (LAP) score is expected in:

    Answer: Chronic myeloid leukemia

    CML neutrophils have low LAP activity, which helps distinguish CML from a leukemoid reaction, where LAP is high.

  6. An automated WBC count is 10.0 x 10^3/µL and the differential shows 25 nRBCs per 100 WBCs. What is the corrected WBC count?

    Answer: 8.0 x 10^3/µL

    Corrected WBC = 10.0 x 100 / (100 + 25) = 8.0 x 10^3/µL.

  7. The Coulter principle counts and sizes blood cells based on:

    Answer: Electrical impedance

    Cells passing through an aperture interrupt a current, and the size of each voltage pulse is proportional to cell volume.

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Sources & references

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  1. americanmedtech.org — Test delivery, exam format, eligibility, passing score, score release, test dates, score validity, renewal, retake policy, exam information · verified Oct 2026
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