CMD Clinical Oncology & Disease Sites Flashcards
6 cards from real CMD practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 6 CMD Clinical Oncology & Disease Sites flashcards as text
In pediatric craniospinal irradiation (CSI), what is a critical dosimetric challenge the dosimetrist must address?
Answer: Matching junctions between cranial and spinal fields without hot/cold spots
CSI requires careful junction management between the cranial whole-brain fields and the posterior spinal field(s) to avoid overdose or underdose at the match line, which can cause late spinal cord injury or recurrence.
For treatment of Hodgkin lymphoma, what contemporary radiation technique limits dose to mediastinal structures?
Answer: Involved-site radiation therapy (ISRT) with IMRT or VMAT
Modern Hodgkin lymphoma treatment uses ISRT (targeting only involved nodes) with IMRT/VMAT, dramatically reducing dose to the heart, lungs, and breast tissue compared to historical mantle fields.
Which GI malignancy is commonly treated with a concurrent chemoradiation regimen using 5-fluorouracil or capecitabine as a radiosensitizer?
Answer: Rectal cancer
Rectal cancer is standardly treated with preoperative concurrent chemoradiation (45–50.4 Gy with 5-FU or capecitabine) to achieve tumor downstaging before surgical resection.
In prostate cancer SBRT, what is a typical dose fractionation schedule used for definitive treatment?
Answer: 36.25 Gy in 5 fractions
Prostate SBRT commonly delivers 36.25 Gy in 5 fractions (7.25 Gy/fraction), exploiting the low α/β ratio (~1.5 Gy) of prostate cancer for high biological effectiveness.
For a patient receiving radiation therapy to the spine for metastatic disease, which dose-limiting structure defines the prescription constraint?
Answer: Spinal cord (maximum point dose)
The spinal cord maximum point dose (e.g., Dmax ≤ 45 Gy conventional or ≤14 Gy in SBRT single fraction) is the primary constraint limiting dose escalation in spinal metastasis treatment.
What is 'elective nodal irradiation' (ENI) in the context of head and neck cancer treatment planning?
Answer: Prophylactic irradiation of lymph node regions at risk for subclinical disease
ENI treats clinically uninvolved nodal levels that have a significant probability of harboring microscopic disease based on the tumor site, histology, and T-stage.