CLS Secondary Causes of Dyslipidemia 2

Question 1

Which thyroid condition is most commonly associated with elevated LDL-C due to decreased LDL receptor expression?

Accepted Answer

Hypothyroidism

Answer

Hypothyroidism reduces LDL receptor activity, leading to impaired LDL clearance and elevated LDL-C levels.

Question 2

A patient with nephrotic syndrome develops hyperlipidemia primarily due to which mechanism?

Accepted Answer

Compensatory hepatic lipoprotein overproduction due to low oncotic pressure

Answer

Nephrotic syndrome causes hepatic overproduction of VLDL and LDL in response to the low oncotic pressure from protein loss.

Question 3

Which medication class used for HIV treatment is most strongly linked to hypertriglyceridemia and insulin resistance?

Accepted Answer

Older protease inhibitors

Answer

Older HIV protease inhibitors (e.g., ritonavir, lopinavir) significantly inhibit lipid metabolism, causing hypertriglyceridemia and insulin resistance.

Question 4

Cushing's syndrome causes dyslipidemia primarily through which mechanism?

Accepted Answer

Cortisol-driven insulin resistance and central adiposity

Answer

Excess cortisol promotes insulin resistance and central obesity, leading to elevated triglycerides, low HDL-C, and often elevated LDL-C.

Question 5

A patient on chronic hemodialysis is most likely to exhibit which lipid abnormality pattern?

Accepted Answer

Hypertriglyceridemia with low HDL-C

Answer

End-stage renal disease is associated with impaired lipoprotein lipase activity, leading to hypertriglyceridemia and low HDL-C.

(CLS) Clinical Lipid Specialist Certification Practice Test

(CLS) Clinical Lipid Specialist Certification Practice Test

CLS Secondary Causes of Dyslipidemia 2