CLS CLS Triglyceride Disorders & Management

Question 1

Which triglyceride level (mg/dL) is classified as 'very high' according to the National Cholesterol Education Program (NCEP) ATP III guidelines?

Accepted Answer

≥500

Answer

≥200

Answer

≥400

Answer

≥300

Question 2

What is the primary mechanism by which fibrates reduce triglyceride levels?

Accepted Answer

Activation of PPAR-α, increasing lipoprotein lipase activity

Answer

Inhibiting HMG-CoA reductase

Answer

Blocking intestinal cholesterol absorption

Answer

Increasing bile acid excretion

Question 3

A patient with triglycerides of 850 mg/dL is at immediate risk for which serious complication?

Accepted Answer

Acute pancreatitis

Answer

Ischemic stroke

Answer

Deep vein thrombosis

Answer

Peripheral artery disease

Question 4

Which lipoprotein is the primary carrier of endogenous triglycerides in the fasting state?

Accepted Answer

VLDL

Answer

Chylomicrons

Answer

IDL

Answer

HDL

Question 5

Which omega-3 fatty acid formulation is FDA-approved at prescription doses specifically for severe hypertriglyceridemia (≥500 mg/dL)?

Accepted Answer

Icosapentaenoic acid (EPA) ethyl esters (Vascepa) and omega-3-acid ethyl esters (Lovaza)

Answer

Fish oil supplements only

Answer

Docosahexaenoic acid (DHA) only

Answer

Alpha-linolenic acid (ALA)

Question 6

Lipoprotein lipase (LPL) deficiency most commonly presents with which triglyceride phenotype?

Accepted Answer

Type I hyperlipoproteinemia with massive chylomicronemia

Answer

Type IIa with isolated LDL elevation

Answer

Type III with IDL accumulation

Answer

Type IV with mild VLDL elevation