CLS Diagnosis & Classification of Dyslipidemia 3

Question 1

A 42-year-old woman has LDL-C of 210 mg/dL, tendon xanthomas, and her father died of MI at age 48. The Dutch Lipid Clinic Network score would classify her as:

Accepted Answer

Definite FH

Answer

Tendon xanthomas alone yield 6 points, placing her at ≥8 points for definite FH in the Dutch Lipid Clinic Network scoring system.

Question 2

Which finding on a fasting lipid panel best indicates the presence of chylomicrons?

Accepted Answer

Plasma that remains turbid after refrigeration

Answer

Chylomicrons float to form a creamy supernatant upon refrigeration overnight, distinguishing them from VLDL which keeps the infranatant turbid.

Question 3

A patient with metabolic syndrome shows TG 200 mg/dL, HDL 38 mg/dL, and small dense LDL particles. This pattern is referred to as:

Accepted Answer

Atherogenic dyslipidemia triad

Answer

The atherogenic dyslipidemia triad—elevated TG, low HDL, and small dense LDL—is a hallmark of insulin resistance and metabolic syndrome.

Question 4

Lp(a) levels are primarily determined by:

Accepted Answer

LPA gene copy number variation (kringle IV type 2 repeats)

Answer

Lp(a) concentrations are 70–90% genetically determined by the number of kringle IV type 2 repeats in the LPA gene, with shorter isoforms producing higher Lp(a) levels.

Question 5

In the ACC/AHA 2018 guidelines, which LDL-C threshold triggers consideration of additional risk-enhancing factors for statin initiation in primary prevention?

Accepted Answer

≥130 mg/dL

Answer

For intermediate-risk patients (7.5–20% 10-year ASCVD risk), an LDL-C ≥70 mg/dL is addressed, but primary prevention guidance focuses the 130 mg/dL threshold for discussion of risk enhancers.

(CLS) Clinical Lipid Specialist Certification Practice Test

(CLS) Clinical Lipid Specialist Certification Practice Test

CLS Diagnosis & Classification of Dyslipidemia 3