CLS Diagnosis & Classification of Dyslipidemia 2

Question 1

A patient has triglycerides of 950 mg/dL. According to the Endocrine Society classification, this level is best described as:

Accepted Answer

Severe hypertriglyceridemia

Answer

Triglycerides ≥500 mg/dL are classified as very high (severe hypertriglyceridemia), which carries risk of pancreatitis.

Question 2

Which lipoprotein pattern is characterized by elevated VLDL and chylomicrons, causing a creamy supernatant and turbid infranatant on refrigerated plasma?

Accepted Answer

Fredrickson Type V

Answer

Fredrickson Type V involves elevations of both VLDL and chylomicrons, producing the classic creamy top layer and turbid bottom on standing plasma.

Question 3

A patient on a standard fasting lipid panel shows total cholesterol 240 mg/dL, triglycerides 130 mg/dL, HDL 45 mg/dL. The Friedewald-estimated LDL-C would be approximately:

Accepted Answer

169 mg/dL

Answer

Friedewald formula: LDL = TC − HDL − (TG/5) = 240 − 45 − 26 = 169 mg/dL.

Question 4

Which of the following conditions most commonly causes secondary hypercholesterolemia?

Accepted Answer

Hypothyroidism

Answer

Hypothyroidism decreases LDL receptor activity and lipoprotein lipase activity, leading to elevated LDL-C and sometimes TG.

Question 5

In the classification of dyslipidemias, 'dysbetalipoproteinemia' is synonymous with which Fredrickson phenotype?

Accepted Answer

Type III

Answer

Type III hyperlipoproteinemia (dysbetalipoproteinemia) is characterized by accumulation of IDL/remnant particles and is associated with apoE2/E2 homozygosity.

(CLS) Clinical Lipid Specialist Certification Practice Test

(CLS) Clinical Lipid Specialist Certification Practice Test

CLS Diagnosis & Classification of Dyslipidemia 2