CLS Cardiovascular Risk Assessment & Management 3

Question 1

In the Reynolds Risk Score, which additional biomarker is incorporated compared to the Framingham Risk Score?

Accepted Answer

High-sensitivity CRP (hsCRP) and family history of premature MI

Answer

The Reynolds Risk Score adds hsCRP and parental history of premature MI to traditional Framingham variables for improved risk discrimination.

Question 2

Which statement about the ankle-brachial index (ABI) as a cardiovascular risk marker is correct?

Accepted Answer

An ABI <0.9 is diagnostic of peripheral artery disease and signals elevated ASCVD risk

Answer

An ABI <0.9 indicates peripheral artery disease, which is an ASCVD risk equivalent that increases overall cardiovascular event risk.

Question 3

A 45-year-old woman is classified as intermediate ASCVD risk. Her hsCRP is 4.2 mg/L. According to JUPITER trial evidence, statin therapy is most likely to benefit patients with which profile?

Accepted Answer

Normal LDL-C (<100 mg/dL) and hsCRP ≥2 mg/L

Answer

The JUPITER trial showed rosuvastatin reduced cardiovascular events in patients with normal LDL-C (<130 mg/dL) but elevated hsCRP (≥2 mg/L).

Question 4

Which cardiovascular risk factor is best addressed by assessing urine albumin-to-creatinine ratio (UACR) in a hypertensive diabetic patient?

Accepted Answer

Detecting early chronic kidney disease as an ASCVD risk enhancer

Answer

Microalbuminuria (UACR 30–300 mg/g) signals early CKD, which is an independent ASCVD risk enhancer beyond traditional risk factors.

Question 5

In secondary prevention, the 2018 ACC/AHA guidelines define 'very high-risk ASCVD' patients as those with major ASCVD events plus which additional criteria?

Accepted Answer

Major ASCVD events plus high-risk conditions such as multiple events or diabetes

Answer

Very high-risk ASCVD is defined by multiple major ASCVD events or one major event plus high-risk conditions (e.g., diabetes, CKD, familial hypercholesterolemia, smoking).

(CLS) Clinical Lipid Specialist Certification Practice Test

(CLS) Clinical Lipid Specialist Certification Practice Test

CLS Cardiovascular Risk Assessment & Management 3