CLS CLS Triglyceride Disorders & Management 2

Question 1

Which dietary modification has the greatest impact on reducing severely elevated triglyceride levels?

Accepted Answer

Restricting total dietary fat intake

Answer

In severe hypertriglyceridemia, reducing total dietary fat (especially in chylomicronemia syndrome) is the most effective dietary intervention.

Question 2

What is the Friedewald equation limitation regarding triglycerides when calculating LDL-C?

Accepted Answer

It is inaccurate when triglycerides exceed 400 mg/dL

Answer

The Friedewald equation (LDL = TC − HDL − TG/5) becomes unreliable when triglycerides exceed 400 mg/dL because the VLDL estimate is inaccurate.

Question 3

Which genetic disorder is characterized by the accumulation of IDL and causes both hypercholesterolemia and hypertriglyceridemia with palmar xanthomas?

Accepted Answer

Type III hyperlipoproteinemia (familial dysbetalipoproteinemia)

Answer

Type III hyperlipoproteinemia (familial dysbetalipoproteinemia) involves ApoE2 homozygosity causing IDL accumulation and characteristic palmar xanthomas.

Question 4

Which medication class is generally contraindicated in patients with triglycerides >500 mg/dL due to risk of worsening hypertriglyceridemia?

Accepted Answer

Estrogen-containing oral contraceptives

Answer

Estrogen-containing oral contraceptives stimulate hepatic VLDL production and can dramatically worsen hypertriglyceridemia.

Question 5

In the REDUCE-IT trial, icosapentaenoic acid (EPA) 4 g/day reduced major cardiovascular events by approximately what percentage in statin-treated patients with elevated triglycerides?

Accepted Answer

25%

Answer

REDUCE-IT demonstrated a 25% relative risk reduction in major adverse cardiovascular events with 4 g/day EPA in statin-treated patients with TG 135–499 mg/dL.

(CLS) Clinical Lipid Specialist Certification Practice Test

(CLS) Clinical Lipid Specialist Certification Practice Test

CLS CLS Triglyceride Disorders & Management 2